Abstract |
Metrizamide is a water-soluble contrast medium used as a diagnostic tool in myelography and cisternography. Despite its accepted safety, its use has been associated with generalized motor seizures, and several cases of this toxicity have been reported. Risk factors include phenothiazine ingestion, seizure history, and large doses of the contrast material. Abnormal electroencephalographic wave patterns, as well as seizure activity, are less frequent after cisternography than myelography. A case of a metrizamide-induced generalized motor seizure following cisternography is reported in a patient with none of the above risk factors. The need for a thorough medication history and the use of prophylactic anticonvulsants in selected patients is discussed.
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Authors | E Saltiel, D C Adelman, J C Ellis, W I Young |
Journal | Drug intelligence & clinical pharmacy
(Drug Intell Clin Pharm)
Vol. 18
Issue 11
Pg. 894-6
(Nov 1984)
ISSN: 0012-6578 [Print] United States |
PMID | 6437782
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Cerebrospinal Fluid Rhinorrhea
(diagnostic imaging)
- Electroencephalography
- Epilepsy, Tonic-Clonic
(chemically induced)
- Female
- Humans
- Metrizamide
(adverse effects)
- Middle Aged
- Myelography
(adverse effects)
- Risk
- Seizures
(chemically induced)
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