Abstract |
Seven women used an ST-1435-releasing intracervical contraceptive device (ST-ICD), inserted immediately after the cessation of menstrual bleeding. Patterns of bleeding and clinical performance were evaluated and plasma concentrations of ST-1435, estradiol, progesterone and gonadotropins were measured by radioimmunoassays. The results of ten months of treatment are presented. There were no uniform patterns of bleeding. No hormonal side-effects were registered. The plasma concentration of ST-1435 reached 100 pg/ml within two hours after insertion of an ST-ICD. No ovulations occurred during the initial three months of treatment. A rapid decline in the plasma concentrations of ST-1435 was observed; during the tenth month the concentration of ST-1435 was under the sensitivity of the radioimmunoassay of ST-1435. Hence, the release of ST-1435 from Silastic was too rapid for long-acting contraceptive purposes.
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Authors | H Kurunmäki, J Toivonen, P L Lähteenmäki, T Luukkainen |
Journal | Contraception
(Contraception)
Vol. 29
Issue 5
Pg. 411-21
(May 1984)
ISSN: 0010-7824 [Print] United States |
PMID | 6430641
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Contraceptive Agents, Female
- Norpregnenes
- Norprogesterones
- Progesterone
- Estradiol
- ST 1435
- Luteinizing Hormone
- Follicle Stimulating Hormone
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Topics |
- Adult
- Cervix Uteri
- Contraceptive Agents, Female
(administration & dosage)
- Estradiol
(blood)
- Female
- Follicle Stimulating Hormone
(blood)
- Humans
- Luteinizing Hormone
(blood)
- Metabolic Clearance Rate
- Norpregnenes
(administration & dosage)
- Norprogesterones
(administration & dosage, blood)
- Ovulation
(drug effects)
- Progesterone
(blood)
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