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Intracervical release of ST-1435 for contraception.

Abstract
Seven women used an ST-1435-releasing intracervical contraceptive device (ST-ICD), inserted immediately after the cessation of menstrual bleeding. Patterns of bleeding and clinical performance were evaluated and plasma concentrations of ST-1435, estradiol, progesterone and gonadotropins were measured by radioimmunoassays. The results of ten months of treatment are presented. There were no uniform patterns of bleeding. No hormonal side-effects were registered. The plasma concentration of ST-1435 reached 100 pg/ml within two hours after insertion of an ST-ICD. No ovulations occurred during the initial three months of treatment. A rapid decline in the plasma concentrations of ST-1435 was observed; during the tenth month the concentration of ST-1435 was under the sensitivity of the radioimmunoassay of ST-1435. Hence, the release of ST-1435 from Silastic was too rapid for long-acting contraceptive purposes.
AuthorsH Kurunmäki, J Toivonen, P L Lähteenmäki, T Luukkainen
JournalContraception (Contraception) Vol. 29 Issue 5 Pg. 411-21 (May 1984) ISSN: 0010-7824 [Print] United States
PMID6430641 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Contraceptive Agents, Female
  • Norpregnenes
  • Norprogesterones
  • Progesterone
  • Estradiol
  • ST 1435
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
Topics
  • Adult
  • Cervix Uteri
  • Contraceptive Agents, Female (administration & dosage)
  • Estradiol (blood)
  • Female
  • Follicle Stimulating Hormone (blood)
  • Humans
  • Luteinizing Hormone (blood)
  • Metabolic Clearance Rate
  • Norpregnenes (administration & dosage)
  • Norprogesterones (administration & dosage, blood)
  • Ovulation (drug effects)
  • Progesterone (blood)

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