Alfentanil-supplemented anaesthesia for short procedures. A double-blind comparison with fentanyl.

Abstract

Eighty unpremedicated female patients undergoing short gynaecological procedures were randomly allocated to four groups and received either alfentanil or fentanyl (double-blind), together with Althesin-oxygen or methohexitone-nitrous oxide'-oxygen. Recovery from anaesthesia was assessed using the post-box test and the deletion of p. There was a significantly greater frequency of vomiting after operation (P less than 0.05) with methohexitone compared with Althesin and with fentanyl compared with alfentanil, and a significantly greater frequency of pain on injection (P less than 0.001) with methohexitone compared with Althesin. The alfentanil groups completed the post-box test significantly earlier after operation than the fentanyl groups (P less than 0.05). We conclude that alfentanil may offer a significant advantage over fentanyl as an analgesic supplement to i.v. anaesthesia for short procedures.

• Authors: M Patrick, B M Eagar, D F Toft, P S Sebel
• Journal: British journal of anaesthesia (Br J Anaesth) Vol. 56 Issue 8 Pg. 861-6 (Aug 1984) ISSN: 0007-0912 [Print] England
• PMID: 6430311 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Adjuvants, Anesthesia
• Alfentanil
• Fentanyl

Topics

• Adjuvants, Anesthesia
• Alfentanil
• Anesthesia, General
• Dilatation and Curettage
• Double-Blind Method
• Female
• Fentanyl (analogs & derivatives, pharmacology)
• Hemodynamics (drug effects)
• Humans
• Random Allocation
• Respiration (drug effects)
• Time Factors