Delineation of anxiety and phobic disorders responsive to monoamine oxidase inhibitors: implications for classification.

Abstract

Studies of the treatment of panic anxiety and various other states with monoamine oxidase (MAO) inhibitors are critically reviewed. It is concluded that MAOIs have differential effects on several dimensions of pathologic anxiety. The association between depression and anxiety states is also reviewed; it is observed that MAOIs effectively treat severe anxiety and phobic disorders without operating strictly via their antidepressant mechanism. In addition, it is proposed that biologic depression and biologic anxiety should be considered to have some independence from one another. Guidelines for the clinical delineation of anxiety disorders are provided, and the clinical and research implications of the proposal for revision of DSM-III anxiety and phobic disorders section, are outlined in detail. It is suggested that anxiety and phobic disorders be classified into endogenous (disease) and exogenous (nondisease) types.

• Authors: D V Sheehan
• Journal: The Journal of clinical psychiatry (J Clin Psychiatry) Vol. 45 Issue 7 Pt 2 Pg. 29-36 (Jul 1984) ISSN: 0160-6689 [Print] United States
• PMID: 6429129 (Publication Type: Journal Article)

Chemical References

• Monoamine Oxidase Inhibitors
• Propiophenones
• Bupropion
• Benzodiazepines
• Dexamethasone
• Hydrocortisone
• Alprazolam

Topics

• Alprazolam
• Anxiety Disorders (classification, diagnosis, drug therapy)
• Benzodiazepines (therapeutic use)
• Bupropion
• Depressive Disorder (drug therapy)
• Dexamethasone
• Fear (drug effects)
• Humans
• Hydrocortisone (blood)
• Manuals as Topic
• Monoamine Oxidase Inhibitors (pharmacology, therapeutic use)
• Panic (drug effects)
• Phobic Disorders (classification, diagnosis, drug therapy)
• Propiophenones (therapeutic use)
• Terminology as Topic