Abstract |
Intravenously administered synthetic hpGRF 1-40 at doses of 0.1, 0.33 and 1.0 microgram/kg increased plasma GH in a dose-dependent fashion in 4 normal prepubertal children. hpGRF 1-40 at the dose of 1.0 microgram/kg stimulated GH release, though to a lesser extent than in normals, in 7 children with isolated GH-deficiency (IGHD) but failed to do so in a patient with craniopharyngioma. In all normal children and 6/7 patients with IGHD, hpGRF 1-40 at all doses used induced a clear and sustained lowering of plasma prolactin levels; this effect was lacking in the patient with craniopharyngioma. hpGRF 1-40 had no effect on plasma FSH, LH, TSH or glucose levels nor did it influence pulse rate, blood pressure, or body temperature. These results indicate that hpGRF 1-40 is a potent stimulus to GH release in normal prepubertal children and holds promise for treatment of GH-deficient children. In addition, in both normal children and children with IGHD, hpGRF 1-40 is a potent suppressor of prolactin levels.
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Authors | C Pintor, V Fanni, S Loche, V Locatelli, S G Cella, F Villa, F Minuto, R Corda, E E Müller |
Journal | Peptides
(Peptides)
1983 Nov-Dec
Vol. 4
Issue 6
Pg. 929-33
ISSN: 0196-9781 [Print] United States |
PMID | 6424103
(Publication Type: Journal Article)
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Chemical References |
- Peptide Fragments
- somatotropin releasing factor 40
- Prolactin
- Growth Hormone
- Growth Hormone-Releasing Hormone
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Topics |
- Adolescent
- Child
- Female
- Growth Hormone
(blood, deficiency, metabolism)
- Growth Hormone-Releasing Hormone
- Humans
- Kinetics
- Male
- Peptide Fragments
- Prolactin
(blood, metabolism)
- Reference Values
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