Abstract |
Hydralazine, labetalol, methyldopa, minoxidil, prazosin, and placebo were compared when added by random allocation to atenolol 100 mg and bendrofluazide 5 mg daily in a series of 238 hypertensive patients inadequately controlled by the beta blocker- diuretic combination. Atenolol was withdrawn in those allocated to labetalol, and minoxidil was given only to men. The order of acceptability was: placebo, hydralazine, prazosin, methyldopa, minoxidil, labetalol. Minoxidil was more effective than the other active drugs, which had similar potency to one another. All the active agents were more effective than placebo. Hydralazine was the most generally suitable third drug, with prazosin a close second. Minoxidil was especially effective in patients with less severe hypertension but the same regimen caused fluid retention in those with more severe disease. Labetalol should probably be introduced at a low dose (150 mg daily) even when replacing full doses of a previously administered beta blocker.
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Authors | D McAreavey, L E Ramsey, L Latham, A D McLaren, A R Lorimer, J L Reid, J I Robertson, M P Robertson, R J Weir |
Journal | British medical journal (Clinical research ed.)
(Br Med J (Clin Res Ed))
Vol. 288
Issue 6411
Pg. 106-11
(Jan 14 1984)
ISSN: 0267-0623 [Print] England |
PMID | 6419809
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antihypertensive Agents
- Hydralazine
- Atenolol
- Methyldopa
- Minoxidil
- Bendroflumethiazide
- Labetalol
- Prazosin
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Topics |
- Adolescent
- Adult
- Aged
- Antihypertensive Agents
(administration & dosage, adverse effects, therapeutic use)
- Atenolol
(therapeutic use)
- Bendroflumethiazide
(therapeutic use)
- Blood Pressure
(drug effects)
- Clinical Trials as Topic
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Humans
- Hydralazine
(therapeutic use)
- Hypertension
(drug therapy)
- Labetalol
(therapeutic use)
- Male
- Methyldopa
(therapeutic use)
- Middle Aged
- Minoxidil
(therapeutic use)
- Prazosin
(therapeutic use)
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