Tumor concentration of platinum in patients with head and neck cancer.

Abstract

Simultaneous concentrations of total plasma platinum, filterable platinum, intact cisplatin, and total tumor platinum were measured for 24 hours after an intravenous bolus of cisplatin in five patients. Tumor concentrations of drug were greater than could be explained on the basis of circulating plasma platinum at the time of biopsy. Intratumor platinum concentrations derived from this study provide guidance for selection of the appropriate drug concentrations for in vitro chemosensitivity testing of head and neck cancer in humans.

• Authors: D E Mattox, L A Sternson, D D Von Hoff, J G Kuhn, A J Repta
• Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (Otolaryngol Head Neck Surg) Vol. 91 Issue 3 Pg. 271-5 (Jun 1983) ISSN: 0194-5998 [Print] England
• PMID: 6410327 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Platinum
• Cisplatin

Topics

• Animals
• Carcinoma, Squamous Cell (analysis, blood, drug therapy)
• Cisplatin (administration & dosage, analysis, therapeutic use)
• Dogs
• Dose-Response Relationship, Drug
• Drug Resistance
• Head and Neck Neoplasms (analysis, blood, drug therapy)
• Humans
• In Vitro Techniques
• Platinum (analysis, blood)