Comparative antitumor activities of 7-N-(p-hydroxyphenyl)mitomycin C (M-83) and mitomycin C.

Abstract

The antitumor activity of 7-N-(p-hydroxyphenyl)mitomycin C (M-83) against 7 kinds of ascitic tumors and 4 kinds of solid tumors was compared with that of mitomycin C (MMC). M-83 showed more potent activities than MMC against ascites sarcoma 180, fibrosarcoma Meth 1, sarcoma Meth A, melanoma B-16, leukemia P388 and lymphoma EL4, by a single intraperitoneal injection. Furthermore, M-83 gave markedly higher chemotherapeutic ratio than MMC in these tumor systems. M-83 was also markedly effective against solid tumors of sarcoma 180, Meth 1, Meth A and Lewis lung carcinoma, by a single intravenous injection. M-83 gave lower myelo-suppression than MMC at the doses which gave almost equal inhibition on the tumor growth of solid Meth 1. M-83 and MMC significantly inhibited the growth of HeLa S3 cells. Cell growth was observed at 24 hours after addition of 3 X 10(-3) mM of drugs, but no growth was shown thereafter. M-83 inhibited more strongly the incorporation of the radioactive precursor into DNA than that into RNA or protein at the concentration of 3 X 10(-3) mM.

• Authors: R Imai, M Morimoto
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 36 Issue 5 Pg. 559-65 (May 1983) ISSN: 0021-8820 [Print] England
• PMID: 6409871 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Mitomycins
• Mitomycin
• 7-N-(4-hydroxyphenyl)mitomycin C

Topics

• Animals
• Antibiotics, Antineoplastic (therapeutic use, toxicity)
• HeLa Cells (drug effects)
• Male
• Mice
• Mice, Inbred Strains
• Mitomycin
• Mitomycins (therapeutic use, toxicity)
• Neoplasms, Experimental (drug therapy)