[Pathogenesis and immunotherapy of insulin-dependent (type I) diabetes mellitus].

Abstract

The association of insulin-dependent (type I) diabetes mellitus with HLA-DR3 and DR4 and with several epidemiological, virological, immunological, and clinical data suggests a heterogenous pathogenesis. the initial lesion in most cases is a virologically induced autoimmune process. It is only rarely that insulin-dependent diabetes results from a pure viral infection or as part of polyendocrine autoimmune deficiencies. The knowledge of the genetical risk factors and of disease-specific humoral and cellular immune deviations exhibits possibilities of successful intervention by means of immunotherapy.

• Authors: J Bertrams
• Journal: Klinische Wochenschrift (Klin Wochenschr) Vol. 61 Issue 6 Pg. 255-63 (Mar 15 1983) ISSN: 0023-2173 [Print] Germany
• Vernacular Title: Zur Pathogenese und Immuntherapie des insulinbedürftigen (Typ I) Diabetes mellitus.
• PMID: 6408297 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• HLA-DR3 Antigen
• HLA-DR4 Antigen
• Insulin

Topics

• Autoimmune Diseases (immunology)
• Diabetes Mellitus (etiology, genetics, immunology, therapy)
• Genes, MHC Class II
• HLA-DR3 Antigen
• HLA-DR4 Antigen
• Humans
• Immunotherapy
• Insulin (physiology)
• Virus Diseases (immunology)