Hypergammaglobulinemic purpura of Waldenström: characterization of circulating immune complexes.

Abstract

Circulating immune complexes were detected in the sera of 7 patients with hypergammaglobulinemic purpura of Waldenström by the following methods: KgB-SP, mRF-LIA, Cc test, ClqBA. Analytical ultracentrifugation showed intermediate complexes between 7S and 19S (16S-19S); simple immunodiffusion of the complexes, purified by 2.5% PEG precipitation, revealed the presence of IgG3, IgA, IgM, Clq, C3 and C4. Constant high titers of rheumatoid activity in the sera in toto and after purification, and normal serum complement levels were also detected.

• Authors: G Serino, F Pitingolo, C Granatieri, V Maresca, F Invernizzi, C Zara, C Zanussi
• Journal: Acta haematologica (Acta Haematol) Vol. 69 Issue 3 Pg. 152-7 ( 1983) ISSN: 0001-5792 [Print] Switzerland
• PMID: 6404097 (Publication Type: Journal Article)

Chemical References

• Antigen-Antibody Complex
• Immunoglobulin A
• Immunoglobulin G
• Immunoglobulin M
• Complement System Proteins
• Rheumatoid Factor

Topics

• Adult
• Antigen-Antibody Complex (analysis, isolation & purification)
• Chromatography, Gel
• Complement System Proteins (analysis)
• Female
• Humans
• Immunodiffusion
• Immunoglobulin A (analysis)
• Immunoglobulin G (analysis)
• Immunoglobulin M (analysis)
• Male
• Middle Aged
• Purpura, Hyperglobulinemic (immunology)
• Rheumatoid Factor (analysis)
• Ultracentrifugation