Influence of excess of retinoid on DMBA carcinogenesis.

Abstract

This paper reports a study on the influence of excess of vitamin A palmitate on the induction and maintenance of oral tumors. Sixty four weanling Syrian hamsters were divided in four groups and painted three times a week, either with 0.5% DMBA or 15% vitamin A palmitate, singly or in combination. A possible mild immune response evoked by vitamin A palmitate is considered responsible for the delayed induction of the tumors. In all animals exposed to carcinogen + vitamin A the induced tumors were small in size and histologically verified as well differentiated epidermoid carcinomas. In control group with sole vitamin A palmitate application the cheek pouch showed considerably increased keratinization.

• Authors: S V Kandarkar, S M Sirsat
• Journal: Neoplasma (Neoplasma) Vol. 30 Issue 1 Pg. 43-50 ( 1983) ISSN: 0028-2685 [Print] Slovakia
• PMID: 6403876 (Publication Type: Journal Article)

Chemical References

• Benz(a)Anthracenes
• Diterpenes
• Retinyl Esters
• Vitamin A
• retinol palmitate
• 9,10-Dimethyl-1,2-benzanthracene

Topics

• 9,10-Dimethyl-1,2-benzanthracene (toxicity)
• Animals
• Basement Membrane (ultrastructure)
• Benz(a)Anthracenes (toxicity)
• Carcinoma, Squamous Cell (chemically induced, prevention & control, ultrastructure)
• Cheek
• Cricetinae
• Diterpenes
• Epithelium (ultrastructure)
• Female
• Male
• Mesocricetus
• Microscopy, Electron
• Mouth Neoplasms (chemically induced, prevention & control, ultrastructure)
• Retinyl Esters
• Time Factors
• Vitamin A (analogs & derivatives, pharmacology)