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Increased solubility of collagen. A biochemical defect in the experimental hydralizine-induced collagen disease-like syndrome.

Abstract
An increase of soluble fractions of collagen and a decrease of insoluble ones was found in the skin of guinea pigs with collagen disease-like syndrome, produced by prolonged treatment with hydralazine. Chromatography studies showed that the collagen alpha chains content in the skin increased and beta-chains decreased under conditions of the development of lupus-like syndrome. The obtained results suggested the inhibition of collagen maturation as one of biochemical defects of connective tissue in drug-induced collagen disease-like syndrome.
AuthorsE Kucharz, M Drózdz
JournalExperimentelle Pathologie (Exp Pathol (Jena)) Vol. 15 Issue 1 Pg. 63-5 ( 1978) ISSN: 0014-4908 [Print] Germany
PMID639926 (Publication Type: Journal Article)
Chemical References
  • Hydralazine
  • Collagen
Topics
  • Animals
  • Chromatography (methods)
  • Collagen (metabolism)
  • Collagen Diseases (chemically induced, metabolism)
  • Hydralazine
  • Solubility
  • Swine
  • Syndrome

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