Abstract |
An increase of soluble fractions of collagen and a decrease of insoluble ones was found in the skin of guinea pigs with collagen disease-like syndrome, produced by prolonged treatment with hydralazine. Chromatography studies showed that the collagen alpha chains content in the skin increased and beta-chains decreased under conditions of the development of lupus-like syndrome. The obtained results suggested the inhibition of collagen maturation as one of biochemical defects of connective tissue in drug-induced collagen disease-like syndrome.
|
Authors | E Kucharz, M Drózdz |
Journal | Experimentelle Pathologie
(Exp Pathol (Jena))
Vol. 15
Issue 1
Pg. 63-5
( 1978)
ISSN: 0014-4908 [Print] Germany |
PMID | 639926
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Animals
- Chromatography
(methods)
- Collagen
(metabolism)
- Collagen Diseases
(chemically induced, metabolism)
- Hydralazine
- Solubility
- Swine
- Syndrome
|