Single-dose regimen of cefonicid for the treatment of uncomplicated infections of the lower urinary tract.

Abstract

Fifty-three women with symptoms of lower urinary tract infection were randomly assigned to treatment with cefonicid administered intramuscularly in a single 1-g dose or to treatment with 500 mg of amoxicillin administered orally three times a day for five to seven days. Urine cultures were obtained before therapy and again at five to 18 days and six to seven weeks after termination of therapy. Forty-one patients had greater than or equal to 2 X 10(4) colony-forming units (cfu)/ml of catheterized urine or greater than or equal to 10(5) cfu/ml of midstream urine. In the cefonicid-treated group, 19 (90%) of 21 patients demonstrated bacteriologic cure at early follow-up. Of the 18 patients seen at late follow-up, 15 were cured and three were reinfected. One patient was lost to late follow-up. In the amoxicillin-treated group, 16 (80%) of 20 patients demonstrated bacteriologic cure at early follow-up. Of the 15 patients available at late follow-up, 14 were cured and one was reinfected. One patient was lost to late follow-up. Cefonicid is an effective single-dose agent in uncomplicated lower urinary tract infection.

• Authors: S I Morgan, R E Pontzer, L M Cortez, S L Guice, W Brannan, R E Krieger, W McNamee, J A Boscia, M E Levison, D Kaye
• Journal: Reviews of infectious diseases (Rev Infect Dis) 1984 Nov-Dec Vol. 6 Suppl 4 Pg. S844-6 ISSN: 0162-0886 [Print] United States
• PMID: 6395274 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Cefamandole
• Cefonicid
• Amoxicillin

Topics

• Adult
• Aged
• Amoxicillin (administration & dosage, therapeutic use)
• Cefamandole (administration & dosage, analogs & derivatives, therapeutic use)
• Cefonicid
• Clinical Trials as Topic
• Enterobacteriaceae Infections (drug therapy)
• Female
• Follow-Up Studies
• Half-Life
• Humans
• Middle Aged
• Random Allocation
• Time Factors
• Urinary Tract Infections (drug therapy)