Abstract |
The safety and clinical efficacy of cefoperazone were evaluated at 149 institutions in Japan. A total of 979 hospitalized patients were treated with cefoperazone alone for 1,059 infections. In the 984 infections evaluated, there was an overall satisfactory clinical response in 824 (83.7%). Cefoperazone was effective in 83.0% of the respiratory tract infections, 84.9% of urinary tract infections, and 89.6% of hepatobiliary tract infections. Clinical response was satisfactory in 90% or more of the cases in which Escherichia coli, Serratia sp, Haemophilus influenzae or Staphylococcus sp were isolated. Sixty percent to 90% of the infections with Klebsiella sp, Enterobacter sp, Proteus sp, and Pseudomonas aeruginosa responded satisfactorily to cefoperazone. Cefoperazone was effective in 76.2% of 260 evaluated cases that had failed to respond to prior treatment with other cephalosporins. The adverse reactions that occurred in 19 (1.9%) of the 979 patients included rash (1%), diarrhea (0.6%), and fever (0.4%). Cefoperazone appears to be extremely useful in the treatment of various infections in hospitalized patients.
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Authors | A Saito, Y Ueda |
Journal | Clinical therapeutics
(Clin Ther)
Vol. 7
Issue 1
Pg. 49-59
( 1984)
ISSN: 0149-2918 [Print] United States |
PMID | 6394129
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Bacterial Infections
(drug therapy, microbiology)
- Cefoperazone
(administration & dosage, adverse effects, therapeutic use)
- Clinical Trials as Topic
- Drug Resistance, Microbial
- Female
- Humans
- Japan
- Male
- Middle Aged
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