Evidence for the presence of M. leprae reactive T lymphocytes in patients with lepromatous leprosy.
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| Abstract |
Evidence for the presence of Mycobacterium leprae reactive T cells in many lepromatous leprosy (LL) patients was obtained using in vitro antigen-induced lymphoproliferative responses. (1) Co-cultures of T enriched cells from LL patients when combined with 2 h adherent cells (AC) from HLA-D compatible tuberculoid leprosy individuals showed significant levels of 3H-thymidine incorporation in the presence of soluble and integral M. leprae antigens. (2) More interestingly, autologous T cell + AC co-cultures also showed significant improvement in antigen-induced lymphoproliferation in nine of 16 lepromatous patients. Insignificant improvement was observed in similar co-cultures of tuberculoid leprosy patients. (3) Addition of exogenous, purified human interleukin-2 (IL-2) to antigen stimulated PBMC from some lepromatous patients showed the best improvement in terms of overall 3H-thymidine incorporation, indicating that lepromatous patients possess T cells which can differentiate to an IL-2 responsive state. Significantly, the level of proliferation varied within the group. A proportion of clinically similar lepromatous patients failed to show improvement by any of the above methods.
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| Authors | I Nath, M Sathish, T Jayaraman, L K Bhutani, A K Sharma |
| Journal | Clinical and experimental immunology (Clin Exp Immunol) Vol. 58 Issue 3 Pg. 522-30 (Dec 1984) ISSN: 0009-9104 [Print] England |
| PMID | 6391762 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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