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Anti-hypoxic effect of piracetam and its interaction with prostacyclin.

Abstract
The anti-hypoxic effect of piracetam was studied using the following experimental methods: hypobaric and anoxic hypoxia in mice, complete ischemia by decapitation in mice, incomplete ischemia by bilateral carotid occlusion in rats and hemic hypoxia in rats. Cinnarizine and vinpocetine were used as reference drugs. In hypobaric hypoxia, anoxic hypoxia, and complete ischemia by decapitation the interaction of piracetam with the effect of prostacyclin (PGI2) was investigated. Piracetam showed anti-hypoxic effect in all the methods used. Its effect was greater than that of cinnarizine and similar to that of vinpocetine. Piracetam potentiated the effect of PGI2 shifting the anti-hypoxic dose-response curve of PGI2 to the left.
AuthorsM Nikolova, R Nikolov, D Milanova
JournalMethods and findings in experimental and clinical pharmacology (Methods Find Exp Clin Pharmacol) Vol. 6 Issue 7 Pg. 367-71 (Jul 1984) ISSN: 0379-0355 [Print] Spain
PMID6390021 (Publication Type: Journal Article)
Chemical References
  • Pyrrolidinones
  • Vinca Alkaloids
  • Cinnarizine
  • vinpocetine
  • Epoprostenol
  • Piracetam
Topics
  • Animals
  • Atmospheric Pressure
  • Cinnarizine (therapeutic use)
  • Drug Synergism
  • Epoprostenol (therapeutic use)
  • Female
  • Hypoxia (drug therapy)
  • Ischemia (drug therapy)
  • Mice
  • Mice, Inbred Strains
  • Piracetam (therapeutic use)
  • Pyrrolidinones (therapeutic use)
  • Rats
  • Rats, Inbred Strains
  • Vinca Alkaloids (therapeutic use)

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