Effects of dipyrone on endotoxin-induced fever, central nervous depression and hypoglycaemia in sheep.

Abstract

Sixteen sheep were divided into four groups and were given saline, Escherichia coli endotoxin at 35 micrograms/kg0.75, dipyrone at 88 mg/kg0.75, or endotoxin and dipyrone intravenously. Plasma glucose concentrations, rectal temperature and depression of central nervous function were assessed at hourly intervals for 10 h and again at 24 h. Dipyrone had no effect on normal sheep but in sheep given endotoxin, it blocked the febrile response and partially blocked the depression effect upon the central nervous system without affecting the hypoglycaemic response.

• Authors: J M Naylor, C A Catanzarro, D S Kronfeld
• Journal: Journal of veterinary pharmacology and therapeutics (J Vet Pharmacol Ther) Vol. 7 Issue 3 Pg. 233-8 (Sep 1984) ISSN: 0140-7783 [Print] England
• PMID: 6387172 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Endotoxins
• Aminopyrine
• Dipyrone

Topics

• Aminopyrine (analogs & derivatives)
• Animals
• Body Temperature
• Brain (drug effects)
• Depression, Chemical
• Dipyrone (therapeutic use)
• Endotoxins (antagonists & inhibitors)
• Escherichia coli
• Fever (drug therapy, veterinary)
• Hypoglycemia (chemically induced, drug therapy)
• Rectum
• Sheep (physiology)
• Sheep Diseases (drug therapy)