Abstract |
In a 6-week double-blind parallel treatment study, dothiepin and amitriptyline were compared to placebo in the treatment of 33 depressed outpatients. Dothiepin and amitriptyline were equally effective in alleviating the symptoms of depressive illness, and both were significantly superior to placebo. The overall incidence of side effects and the frequency and severity of blurred vision, dry mouth, and drowsiness were significantly less with dothiepin than with amitriptyline. Dothiepin also produced fewer CNS and cardiovascular effects. There were no clinically important changes in laboratory parameters. Dothiepin thus was found to be an effective antidepressant drug associated with fewer side effects than amitriptyline in the treatment of depressed outpatients.
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Authors | N E Stratas |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
Vol. 45
Issue 11
Pg. 466-9
(Nov 1984)
ISSN: 0160-6689 [Print] United States |
PMID | 6386793
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Dibenzothiepins
- Placebos
- Amitriptyline
- Dothiepin
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Topics |
- Ambulatory Care
- Amitriptyline
(adverse effects, therapeutic use)
- Clinical Trials as Topic
- Depressive Disorder
(drug therapy, psychology)
- Dibenzothiepins
(therapeutic use)
- Dothiepin
(adverse effects, therapeutic use)
- Double-Blind Method
- Humans
- Placebos
- Psychiatric Status Rating Scales
- Sleep Stages
- Vision Disorders
(chemically induced)
- Xerostomia
(chemically induced)
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