HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effect of acetazolamide on insulin sensitivity in myotonic disorders.

Abstract
Acetazolamide is effective treatment for myotonia in certain patients with myotonia congenita. Since potassium metabolism may be abnormal in myotonia congenita, we studied the effect of acetazolamide administration on potassium regulation and glucose disposal, using the euglycemic insulin clamp technique in patients with myotonic disorders and in normal subjects. Glucose disposal was normal in patients with myotonia congenita; administration of acetazolamide increased glucose disposal in normal subjects and in patients with myotonia congenita. By contrast, patients with myotonic dystrophy showed insulin resistance and decreased glucose disposal that was not improved by acetazolamide administration. Patients with myotonia congenita had elevated potassium levels in the basal state and a greater fall in potassium level during the insulin clamp procedure than controls. Patients with myotonic dystrophy had normal or low basal potassium levels and a subnormal decrease in potassium level during the insulin clamp procedure. Administration of acetazolamide did not alter these abnormalities in potassium metabolism in patients with either myotonia congenita or myotonic dystrophy.
AuthorsA Corbett, W Kingston, R C Griggs, R T Moxley 3rd
JournalArchives of neurology (Arch Neurol) Vol. 41 Issue 7 Pg. 740-3 (Jul 1984) ISSN: 0003-9942 [Print] United States
PMID6378152 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Insulin
  • Glucose
  • Acetazolamide
  • Potassium
Topics
  • Acetazolamide (therapeutic use)
  • Adult
  • Aged
  • Female
  • Glucose (metabolism)
  • Humans
  • Insulin (metabolism)
  • Male
  • Middle Aged
  • Myotonia Congenita (drug therapy, metabolism)
  • Myotonic Dystrophy (drug therapy, metabolism)
  • Potassium (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: