Regression of androgen-related hepatic tumors in patients with Fanconi's anemia following marrow transplantation.

Abstract

Two patients with Fanconi's anemia treated for 5 years with oxymetholone developed hepatic function abnormalities in association with hepatic tumors demonstrated by isotope liver-spleen scan or abdominal echogram. The lesions resolved over a period of 26 months after allogeneic marrow transplantation, and the patients are alive and well 3 and 4 years following transplantation. The course of these patients indicates that marrow transplantation for Fanconi's anemia allows the withdrawal of androgens and subsequent regression of androgen-related hepatic tumors in patients who might otherwise have a fatal outcome.

• Authors: E Schmidt, H J Deeg, R Storb
• Journal: Transplantation (Transplantation) Vol. 37 Issue 5 Pg. 452-5 (May 1984) ISSN: 0041-1337 [Print] United States
• PMID: 6375000 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Oxymetholone

Topics

• Adolescent
• Anemia, Aplastic (therapy)
• Bone Marrow Transplantation
• Child
• Child, Preschool
• Fanconi Anemia (complications, therapy)
• Female
• Humans
• Liver Neoplasms (complications, pathology)
• Male
• Neoplasm Regression, Spontaneous
• Neoplasms, Hormone-Dependent (pathology)
• Oxymetholone (therapeutic use)