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Comparison of single dose netilmicin with a five-day course of co-trimoxazole for uncomplicated urinary tract infections.

Abstract
Women with uncomplicated urinary tract infections were randomly allocated to either a single 150 mg intramuscular dose of netilmicin or a standard five-day course of oral co-trimoxazole. Twenty-one of 22 were cured with netilmicin and all 20 with co-trimoxazole. No patient treated with netilmicin developed any side effects or obvious toxicity. Following co-trimoxazole one woman developed a severe skin rash and another nausea. Netilmicin is another drug which is highly effective when used in a single dose regimen for the treatment of uncomplicated urinary tract infections. There are many advantages of this approach to the management of a common clinical problem.
AuthorsR R Bailey, E Blake, B A Peddie
JournalThe New Zealand medical journal (N Z Med J) Vol. 97 Issue 754 Pg. 262-4 (Apr 25 1984) ISSN: 0028-8446 [Print] New Zealand
PMID6374533 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Drug Combinations
  • Gentamicins
  • Netilmicin
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Trimethoprim
  • Sulfamethoxazole
Topics
  • Administration, Oral
  • Adolescent
  • Adult
  • Clinical Trials as Topic
  • Drug Combinations (administration & dosage)
  • Escherichia coli Infections (drug therapy)
  • Female
  • Gentamicins (administration & dosage)
  • Humans
  • Injections, Intramuscular
  • Middle Aged
  • Netilmicin (administration & dosage)
  • Prospective Studies
  • Random Allocation
  • Staphylococcal Infections (drug therapy)
  • Sulfamethoxazole (administration & dosage)
  • Trimethoprim (administration & dosage)
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Urinary Tract Infections (drug therapy, etiology)

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