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Surgical closure of patent ductus arteriosus in 268 preterm infants.

Abstract
Over a 2 year period ending in April, 1981, 268 premature infants with birth weight below 1,750 gm underwent operation for a "hemodynamically significant" patent ductus arteriosus. Operations were performed in 13 centers participating in a collaborative study, which was primarily designed to evaluate the role of indomethacin in the management of patent ductus arteriosus. No patient died during the operations, which were done at a median age of 10 days. Eight infants (3%) died within 36 hours after operation. In only one was the death directly attributable to the operative procedure. Hospital mortality (23%) and postoperative morbidity, which included bronchopulmonary dysplasia, pneumothorax, and sepsis, were unrelated to birth weight, age at operation, and degree of preexisting pulmonary disease or preoperative treatment of the infant with indomethacin. Results indicate that surgical ligation is a safe and effective procedure for treating patent ductus arteriosus with large left-to-right shunting in small premature infants.
AuthorsH R Wagner, R C Ellison, S Zierler, P Lang, D M Purohit, D Behrendt, J A Waldhausen
JournalThe Journal of thoracic and cardiovascular surgery (J Thorac Cardiovasc Surg) Vol. 87 Issue 6 Pg. 870-5 (Jun 1984) ISSN: 0022-5223 [Print] United States
PMID6374300 (Publication Type: Clinical Trial, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Indomethacin
Topics
  • Clinical Trials as Topic
  • Double-Blind Method
  • Ductus Arteriosus, Patent (complications, drug therapy, mortality, surgery)
  • Female
  • Humans
  • Indomethacin (therapeutic use)
  • Infant, Newborn
  • Infant, Premature, Diseases (complications, surgery)
  • Male
  • Postoperative Complications
  • Preoperative Care

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