Pharmacology of nomifensine: a review of animal studies.

Abstract

Nomifensine has demonstrated efficacy in several animal models that have been found to be predictive of clinical antidepressant activity, and has also been found to have a low potential for both cardiovascular and anticholinergic side effects. A comparison of nomifensine's profile with those of standard antidepressant agents shows this drug to possess clear advantages which may make it an attractive choice for the treatment of endogenous depression.

• Authors: S Fielding, M R Szewczak
• Journal: The Journal of clinical psychiatry (J Clin Psychiatry) Vol. 45 Issue 4 Pt 2 Pg. 12-20 (Apr 1984) ISSN: 0160-6689 [Print] United States
• PMID: 6370970 (Publication Type: Journal Article, Review)

Chemical References

• Isoquinolines
• Nomifensine
• Reserpine
• Adenylyl Cyclases
• Acetylcholine
• Imipramine
• Dopamine

Topics

• Acetylcholine (pharmacology)
• Adenylyl Cyclases (metabolism)
• Aggression (drug effects)
• Animals
• Behavior, Animal (drug effects)
• Brain Chemistry (drug effects)
• Corpus Striatum (drug effects, enzymology)
• Depressive Disorder (drug therapy)
• Dopamine (metabolism)
• Drug Evaluation, Preclinical
• Electrocardiography
• Guinea Pigs
• Humans
• Hypotension (chemically induced)
• Imipramine (adverse effects, pharmacology)
• Isoquinolines (pharmacology)
• Mice
• Motor Activity (drug effects)
• Myocardial Contraction (drug effects)
• Nomifensine (adverse effects, pharmacology, therapeutic use)
• Rats
• Reserpine (adverse effects, pharmacology)