Long-term safety and efficacy of glipizide.

Abstract

We studied the effect of long-term glipizide therapy in a small group of closely monitored patients. Fasting plasma glucose, glucose tolerance, glucose-stimulated insulin secretion, and insulin sensitivity were measured on multiple occasions throughout the investigation. Our observations show that glipizide therapy is effective in certain patients with noninsulin-dependent diabetes mellitus over a prolonged time period. The major effect of the drug appears to be mediated by its alteration of insulin sensitivity, but glipizide also causes a sustained increase in glucose-stimulated insulin secretion in most patients.

• Authors: M N Feinglos, H E Lebovitz
• Journal: The American journal of medicine (Am J Med) Vol. 75 Issue 5B Pg. 60-6 (Nov 30 1983) ISSN: 0002-9343 [Print] United States
• PMID: 6369969 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Blood Glucose
• Insulin
• Sulfonylurea Compounds
• Glipizide

Topics

• Blood Glucose (metabolism)
• Diabetes Mellitus, Type 2 (drug therapy, metabolism)
• Female
• Glipizide (adverse effects, therapeutic use)
• Glucose Tolerance Test
• Humans
• Insulin (metabolism)
• Insulin Resistance
• Male
• Middle Aged
• Sulfonylurea Compounds (therapeutic use)
• Time Factors