[Isolated liver perfusion in advanced metastases of colorectal cancers].

Abstract

A special cannulation system was developed in order to completely isolate the liver in an extracorporeal circuit. Isolated hyperthermic liver perfusion at 40 degrees C with an average dosage of 1000 mg 5-FU was performed in 32 patients with liver metastases (29 colorectal carcinomas, 2 carcinoids, 1 primary hepatoma). 12 patients who had an overall 45% tumor invasion of the entire liver-volume as measured in CT-scan were treated exclusively by isolated liver perfusion. In that group median survival was 8 months and death occurred in the presence of extrahepatic metastases. Better results are achieved with isolated liver perfusion followed by intraarterial short-time infusions (Mitomycin C/5-FU) via an Implantofix catheter. Median actual survival in this group is 12 months, the longest follow-up period is 23 months.

• Authors: K R Aigner, H Walther, J C Tonn, K H Link, P Schoch, K Schwemmle
• Journal: Onkologie (Onkologie) Vol. 7 Issue 1 Pg. 13-21 (Feb 1984) ISSN: 0378-584X [Print] Switzerland
• Vernacular Title: Die isolierte Leberperfusion bei fortgeschrittenen Metastasen kolorektaler Karzinome.
• PMID: 6369202 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Fluorouracil

Topics

• Chemotherapy, Cancer, Regional Perfusion (instrumentation)
• Colonic Neoplasms (drug therapy)
• Fluorouracil (blood, therapeutic use)
• Humans
• Liver Neoplasms (drug therapy, secondary)
• Male
• Middle Aged
• Prognosis
• Rectal Neoplasms (drug therapy)