Tumour cell death: the probable cause of increased polyamine levels in physiological fluids.

Abstract

The occurrence of extracellular polyamines in Ehrlich ascites tumour-bearing mice was studied in relation to tumour growth. The concentration of putrescine and spermidine in cell-free ascites fluid and serum was found to increase significantly with increasing tumour mass. Data is presented which suggest that the observed accumulation of extracellular polyamines is a result of a continuous release from dead or dying tumour cells. This observation is consistent with the notion that extracellular polyamines accumulate during tumour growth and following radio- and chemotherapy as a result of tumour cell death, and emphasizes the potential clinical usefulness of the polyamine analysis for evaluating tumor cell kill.

• Authors: O Heby, G Andersson
• Journal: Acta pathologica et microbiologica Scandinavica. Section A, Pathology (Acta Pathol Microbiol Scand A) Vol. 86 Issue 1 Pg. 17-20 (Jan 1978) ISSN: 0365-4184 [Print] Denmark
• PMID: 636885 (Publication Type: Journal Article)

Chemical References

• Spermidine
• Putrescine

Topics

• Animals
• Carcinoma, Ehrlich Tumor (metabolism)
• Cell Division
• Cell Survival
• Mice
• Neoplasm Transplantation
• Putrescine (metabolism)
• Spermidine (metabolism)