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Toxicity of vinyl chloride and poly(vinyl chloride): a critical review.

Abstract
In 1974, vinyl chloride (VC) was first reported in the open scientific literature to induce angiosarcoma of the liver both in humans and in animals. Additional research has now demonstrated the carcinogenicity of VC to other organs and at lower concentrations. The target organs for VC now clearly include the liver, brain and the lung, and probably the lymphohematopoietic system. The evidence for a carcinogenic risk has been extended to jobs associated with poly(vinyl chloride) exposure. Cases of liver angiosarcoma have been reported among individuals employed in PVC fabrication facilities and an epidemiological study has demonstrated a significant association between exposure to PVC dust and the risk of lung cancer mortality. Cases of angiosarcoma of the liver also have been reported among individuals living in near proximity to vinyl chloride-poly(vinyl chloride) plants. An association between PVC dust and pneumoconiosis also has been demonstrated. On the basis of findings, prudent control of PVC dust in the industrial setting is indicated.
AuthorsJ K Wagoner
JournalEnvironmental health perspectives (Environ Health Perspect) Vol. 52 Pg. 61-6 (Oct 1983) ISSN: 0091-6765 [Print] United States
PMID6360677 (Publication Type: Journal Article, Review)
Chemical References
  • Polyvinyls
  • Vinyl Compounds
  • Polyvinyl Chloride
  • Vinyl Chloride
Topics
  • Environmental Exposure
  • Hemangiosarcoma (chemically induced)
  • Humans
  • Liver Neoplasms (chemically induced)
  • Lung Neoplasms (chemically induced)
  • Male
  • Middle Aged
  • Neoplasms (chemically induced)
  • Occupational Diseases (chemically induced)
  • Pneumoconiosis (etiology)
  • Polyvinyl Chloride (adverse effects)
  • Polyvinyls (adverse effects)
  • Vinyl Chloride (adverse effects)
  • Vinyl Compounds (adverse effects)

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