Abstract |
In 50 patients transplanted for acute or chronic leukemia we studied the correlation between the number of infused bone marrow cells/kg recipient body weight and the time needed for engraftment. Engraftment was arbitrarily defined as the first day of 1 X 10(9) leukocytes/l and of 20 X 10(9) reticulocytes/l after the posttransplantation nadir. There is a negative non-linear correlation between the duration of leukopenia following marrow transplantation and the amount of transfused nucleated cells (p = 0.01). Since the incidence of infectious or hemorrhagic complications depends directly on the duration of aplasia it is justifiable to give a maximal cell dose.
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Authors | D Niederwieser, A Gratwohl, M Oberholzer, B Osterwalder, C Nissen, B Speck |
Journal | Blut
(Blut)
Vol. 47
Issue 6
Pg. 355-60
(Dec 1983)
ISSN: 0006-5242 [Print] Germany |
PMID | 6360252
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Acute Disease
- Bone Marrow Transplantation
- Dose-Response Relationship, Immunologic
- Granulocytes
- Humans
- Kinetics
- Leukemia
(therapy)
- Leukemia, Lymphoid
(therapy)
- Leukemia, Myeloid
(therapy)
- Leukocyte Count
- Reticulocytes
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