Effect of low dose 1 alpha-hydroxycholecalciferol on glomerular filtration rate in moderate renal failure.

Abstract

Serial measurements of 51Cr edetic acid clearance were made over a period of one year in two groups of 8 children, in a double blind trial of 1 alpha-hydroxycholecalciferol (10 ng/kg/day) and calciferol (670 ng/kg/day). Glomerular filtration rate (GFR) at the beginning of the trial was 20-50 ml/min/1.73 m2; it rose in the children given 1 alpha-hydroxycholecalciferol (group A) after 6 months but was not appreciably different from the pretreatment value after 12 months. The GFR in the children given calciferol (group B) showed no significant difference at 6 or 12 months. Parathyroid hormone values fell markedly in group A after 6 months but not in group B. Quantitative bone histology improved considerably in group A but not in group B at 12 months. Low dose 1 alpha-hydroxycholecalciferol may be used effectively for renal osteodystrophy in children with moderate but stable renal failure without jeopardising renal function.

• Authors: F U Eke, M H Winterborn
• Journal: Archives of disease in childhood (Arch Dis Child) Vol. 58 Issue 10 Pg. 810-3 (Oct 1983) ISSN: 1468-2044 [Electronic] England
• PMID: 6357106 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Hydroxycholecalciferols
• Parathyroid Hormone
• Phosphates
• Calcium
• alfacalcidol

Topics

• Adolescent
• Calcium (blood)
• Child
• Chronic Kidney Disease-Mineral and Bone Disorder (etiology, prevention & control)
• Clinical Trials as Topic
• Double-Blind Method
• Glomerular Filtration Rate (drug effects)
• Humans
• Hydroxycholecalciferols (pharmacology, therapeutic use)
• Kidney Failure, Chronic (complications, metabolism)
• Parathyroid Hormone (blood)
• Phosphates (blood)