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Nonketotic hyperglycemia associated with loxapine and amoxapine: case report.

Abstract
A case of nonketotic hyperglycemic coma associated with the recent introduction of loxapine is presented. Drug discontinuation led to a return of normal fasting blood glucose. Later challenge with amoxapine was also associated with acute hyperglycemia. Their common metabolite, 7-OH amoxapine, is implicated.
AuthorsG Tollefson, T Lesar
JournalThe Journal of clinical psychiatry (J Clin Psychiatry) Vol. 44 Issue 9 Pg. 347-8 (Sep 1983) ISSN: 0160-6689 [Print] United States
PMID6355071 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Dibenzoxazepines
  • Insulin
  • Loxapine
  • Amoxapine
Topics
  • Amoxapine (adverse effects, metabolism)
  • Bipolar Disorder (drug therapy)
  • Diabetic Coma (chemically induced)
  • Dibenzoxazepines (adverse effects)
  • Female
  • Humans
  • Hyperglycemic Hyperosmolar Nonketotic Coma (chemically induced)
  • Insulin (metabolism)
  • Insulin Secretion
  • Loxapine (adverse effects, metabolism)
  • Middle Aged

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