S-100 protein in tumors of cartilage and bone. An immunohistochemical study.

Abstract

Using the peroxidase-antiperoxidase (PAP) immunohistochemical method, S-100 protein was found in well-differentiated chondrocytes of chondroma, chondroblastoma, mesenchymal chondrosarcoma, and osteosarcoma. It was not detected in osteoma, osteoblastoma, giant cell tumor, and Ewing's tumor. The presence of S-100 protein in tumorous chondrocytes and chondroblasts suggests that this protein may be a marker of chondrocyte origin and should not be considered a specific marker for nerve tissue.

• Authors: Y Nakamura, L E Becker, A Marks
• Journal: Cancer (Cancer) Vol. 52 Issue 10 Pg. 1820-4 (Nov 15 1983) ISSN: 0008-543X [Print] United States
• PMID: 6354416 (Publication Type: Journal Article)

Chemical References

• S100 Proteins

Topics

• Adolescent
• Bone Neoplasms (analysis, surgery)
• Child
• Chondroblastoma (analysis)
• Chondroma (analysis)
• Chondrosarcoma (analysis)
• Female
• Femoral Neoplasms (analysis)
• Histocytochemistry
• Humans
• Immunoenzyme Techniques
• Male
• Osteosarcoma (analysis)
• S100 Proteins (analysis)