Abstract |
In a randomized controlled, double-blind clinical trial with 45 patients with moderate hypertension atenolol 100 mg and penbutolol 40 mg were equally effective in lowering the blood pressure. During the 6 weeks of treatment there was no change in body weight and serious side-effects were not observed, but bradycardia occurred more frequently with atenolol than with penbutolol. Withdrawal of medication during the final week of the study did not cause any adverse reaction.
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Authors | L D Lameijer, J J Houtzagers, L A Voermans |
Journal | European heart journal
(Eur Heart J)
Vol. 4 Suppl D
Pg. 53-6
(Jul 1983)
ISSN: 0195-668X [Print] England |
PMID | 6352272
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Propanolamines
- Atenolol
- Penbutolol
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Topics |
- Adult
- Atenolol
(therapeutic use)
- Blood Pressure
- Clinical Trials as Topic
- Diastole
- Double-Blind Method
- Female
- Humans
- Hypertension
(drug therapy)
- Male
- Middle Aged
- Penbutolol
(therapeutic use)
- Propanolamines
(therapeutic use)
- Pulse
- Systole
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