[Prevention of preoperative infection with metronidazole].

Abstract

We practiced a preoperative prophylaxis with 1.5g metronidazole daily starting three days before operation because of the increasing knowledge about the importance of anaerobic microorganisms, causing nosocomial infections. By this regime we saw a significant decrease of postoperative morbidity, detected by means of postoperative febrile temperatures and laparotomy wound abscesses. Bacteriological examinations before and after prophylaxis revealed a relatively high elimination of anaerobic isolates without influence on the aerobic and physiologic flora. In 66% of the cases with infections we isolate anaerobic strains. In cases of pelvic inflammatory diseases metronidazole is to be recommended both prophylactically and therapeutically. There is no resistance against metronidazole.

• Authors: G Göbel, M Link, E Hillmann
• Journal: Zentralblatt fur Gynakologie (Zentralbl Gynakol) Vol. 105 Issue 11 Pg. 720-5 ( 1983) ISSN: 0044-4197 [Print] Germany
• Vernacular Title: Präoperative Infektionsprophylaxe mit Metronidazol.
• PMID: 6349182 (Publication Type: English Abstract, Journal Article)

Chemical References

• Metronidazole

Topics

• Abscess (microbiology, prevention & control)
• Bacteriological Techniques
• Female
• Genital Diseases, Female (surgery)
• Humans
• Metronidazole (therapeutic use)
• Pregnancy
• Premedication
• Surgical Wound Infection (microbiology, prevention & control)
• Vagina (microbiology)