A new treatment for cutaneous candidiasis: sulconazole nitrate cream 1%.

Abstract

Sulconazole nitrate cream 1%, a new topical imidazole compound with a broad antifungal activity, was compared to its vehicle and to miconazole nitrate cream 2% in two double-blind parallel studies involving 96 patients with cutaneous candidiasis. Once daily application of sulconazole was as effective as twice daily application of miconazole and produced KOH and culture cures in 100% and 88% of patients, respectively. No systemic adverse reactions were reported. One vehicle-treated patient developed itching; six sulconazole- and three miconazole-treated patients developed erythema and/or pruritus, which was mild and transient. Sulconazole used bid was significantly superior to its vehicle and produced KOH and culture cures in 100% of patients.

• Authors: L Tanenbaum, C Anderson, M Rosenberg, A Dorr
• Journal: International journal of dermatology (Int J Dermatol) Vol. 22 Issue 5 Pg. 318-20 (Jun 1983) ISSN: 0011-9059 [Print] England
• PMID: 6347921 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Antifungal Agents
• Imidazoles
• Ointments
• sulconazole

Topics

• Administration, Topical
• Antifungal Agents (administration & dosage)
• Candidiasis, Cutaneous (drug therapy)
• Clinical Trials as Topic
• Double-Blind Method
• Humans
• Imidazoles (administration & dosage)
• Ointments
• Random Allocation