Abstract |
1 A survey is given of the use of chelating agents in the treatment of metal poisonings. 1 The complexing agents in established clinical use are the polyaminopolycarboxylic acid EDTA ( ethylenediamine tetraacetate) and the thiols BAL (2, 3-dimercaptopropanol) and D-penicillamine. Desferrioxamine is useful in the treatment of iron overloading. 2 The theoretical foundation of the metal- ligand interaction and some general principles of value in the search for new metal antidotes are outlined. 3 Recent research has shown that 2, 3-dimercaptosuccinic acid (DMS) and 2, 3-dimercaptopropane-1-sulphonate ( DMPS) are effective in mercury and arsenic poisonings. 4 DMS and DMPS are of significantly lower toxicity than BAL, and they can be administered orally or intravenously. 5 A particularly low toxicity of DMS is reported from clinical and experimental studies, and this agent may be useful against several metal poisonings including mercury, lead and gold.
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Authors | J Aaseth |
Journal | Human toxicology
(Hum Toxicol)
Vol. 2
Issue 2
Pg. 257-72
(Apr 1983)
ISSN: 0144-5952 [Print] England |
PMID | 6345341
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
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Topics |
- Animals
- Brain
(metabolism)
- Chelating Agents
(metabolism, therapeutic use, toxicity)
- Chemical Phenomena
- Chemistry
- Drug Stability
- Humans
- Kinetics
- Metals
(poisoning)
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