A randomized trial comparing cadexomer iodine and standard treatment in the out-patient management of chronic venous ulcers.
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| Abstract |
Ninety-three patients with treatment-resistant venous ulcers were included in a multicentre randomized trial to compare cadexomer iodine and the standard treatment used in each centre combined with compression bandages, in healing venous ulcers. The mean duration of ulcers before the trial was more than 2 years. With standard treatment the mean ulcer size increased slightly during the 6-week trial whereas with cadexomer iodine the ulcer size was significantly reduced. Cadexomer iodine was more effective than standard treatment for reduction of pain, removal of pus and debris, removal of exudate, stimulation of granulation and reduction of surrounding erythema. Bacterial infection of ulcers increased or did not change during treatment with the standard therapy whereas cadexomer iodine significantly reduced infection with Staphylococcus aureus, Pseudomonas aeruginosa and other pathogenic organisms. A correlation was seen between the time taken to reduce or eliminate infection with Staphylococcus aureus and rate of ulcer healing. Four patients complained of transient pain in the ulcer after application of the cadexomer iodine. It is concluded that cadexomer iodine increased the rate of healing of infected chronic venous ulcers.
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| Authors | E Skog, B Arnesjö, T Troëng, J E Gjöres, L Bergljung, J Gundersen, T Hallböök, Y Hessman, L Hillström, T Månsson, U Eilard, B Eklöff, G Plate, L Norgren |
| Journal | The British journal of dermatology (Br J Dermatol) Vol. 109 Issue 1 Pg. 77-83 (Jul 1983) ISSN: 0007-0963 [Print] England |
| PMID | 6344906 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial) |
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