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Randomized study for the treatment of adult advanced Hodgkin's disease: mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) versus lomustine, vinblastine, and prednisone.

Abstract
Forty-seven patients with advanced Hodgkin's disease were entered in a prospective, randomized trial comparing MOPP (mechlorethamine, vincristine, procarbazine, and prednisone) with a regimen containing lomustine (CCNU), vinblastine, and prednisone (CCNU-VP). Both groups were comparable for the variables of age, stage, substage (symptoms), histology, prior radiation, and sites of involvement. Seventy-two percent of CCNU-VP-treated patients achieved a pathologically documented complete remission (CR) compared to 41% of the MOPP-treated group. Two additional patients treated with MOPP had remission documented only clinically but have been long-term, disease-free survivors. There was a greater frequency of CR in the patients who had received previous irradiation when compared to patients with no prior irradiation. After a median follow-up of greater than 89 months, there is no statistical difference between the two treatment groups in survival (45% for MOPP and 60% for CCNU-VP). Further, no statistical difference in survival for the two treatment groups was noted when compared by histology, stage, or symptoms. The CCNU-VP combination was better tolerated with significantly less nausea and emesis. The alternative drug regimen of CCNU-VP appears to be as effective as MOPP in producing CR and long-term survival in patients with advanced Hodgkin's disease.
AuthorsH A Liebman, G J Hum, W W Sheehan, V M Ryden, J R Bateman
JournalCancer treatment reports (Cancer Treat Rep) Vol. 67 Issue 5 Pg. 413-9 (May 1983) ISSN: 0361-5960 [Print] United States
PMID6342771 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Antineoplastic Agents
  • Nitrosourea Compounds
  • Procarbazine
  • Mechlorethamine
  • Vincristine
  • Vinblastine
  • Lomustine
  • Prednisone
Topics
  • Adult
  • Antineoplastic Agents (administration & dosage, adverse effects)
  • Antineoplastic Combined Chemotherapy Protocols
  • Clinical Trials as Topic
  • Drug Therapy, Combination
  • Female
  • Hodgkin Disease (drug therapy)
  • Humans
  • Lomustine (administration & dosage, adverse effects)
  • Male
  • Mechlorethamine (administration & dosage, adverse effects)
  • Nitrosourea Compounds (administration & dosage)
  • Prednisone (administration & dosage, adverse effects)
  • Procarbazine (administration & dosage, adverse effects)
  • Prognosis
  • Prospective Studies
  • Random Allocation
  • Vinblastine (administration & dosage, adverse effects)
  • Vincristine (administration & dosage, adverse effects)

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