Treatment of otitis externa with miconazole nitrate. A comparative study involving 85 cases.

Abstract

The hazards of neomycin in local preparations have recently been re-emphasized. Eighty-five patients with otitis externa were treated with one of two preparations between August 1980 and April 1982 -- 54 were treated with a cream containing miconazole nitrate and hydrocortisone (Daktacort; Janssen) and 31 with a preparation containing neomycin (Kenacomb; Squibb); Sixty eight per cent of the patients were cured within 1 week with both preparations. Most treatment failures were due to a resistant Pseudomonas aeruginosa. The miconazole cream proved as effective as the preparation containing neomycin in the first-line treatment of otitis externa. A gentamicin-containing steroid ointment was effective against the Pseudomonas infection.

• Authors: J P Bak, D J Wagenfeld
• Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde (S Afr Med J) Vol. 63 Issue 15 Pg. 562-3 (Apr 09 1983) ISSN: 0256-9574 [Print] South Africa
• PMID: 6342163 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Imidazoles
• Miconazole
• Neomycin

Topics

• Clinical Trials as Topic
• Humans
• Imidazoles (therapeutic use)
• Miconazole (therapeutic use)
• Neomycin (therapeutic use)
• Otitis Externa (drug therapy)