Abstract |
Pre-transplant splenectomy is controversial. We compared 21 nondiabetic, transfused recipients of first cadaver kidney grafts who underwent pre-transplant splenectomy for steroid-resistant leukopenia to 114 without steroid-resistant leukopenia. Kidney graft survivals at 2 years were 80.2 plus or minus 8.9 and 48.5 plus or minus 5.3 per cent, respectively (p less than 0.05). The 2-year actuarial patient survivals were not significantly different (89.6 plus or minus 7.0 versus 87.8 plus or minus 3.9 per cent). Azathioprine doses and serum creatinine levels at 1 year were not significantly different. Pre-transplant splenectomy for steroid-resistant leukopenia resulted in a significant decrease in kidney graft losses owing to rejection without an increased risk of death of sepsis or thromboembolism.
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Authors | J M Barry, B Larson, S M Fischer, D J Norman, W M Bennett |
Journal | The Journal of urology
(J Urol)
Vol. 129
Issue 3
Pg. 479-80
(Mar 1983)
ISSN: 0022-5347 [Print] United States |
PMID | 6339747
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Azathioprine
(therapeutic use)
- Cadaver
- Graft Survival
- Humans
- Kidney Transplantation
- Leukopenia
(therapy)
- Splenectomy
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