Beneficial effect of pre-transplant splenectomy for leukopenia in primary cadaver kidney transplants.

Abstract

Pre-transplant splenectomy is controversial. We compared 21 nondiabetic, transfused recipients of first cadaver kidney grafts who underwent pre-transplant splenectomy for steroid-resistant leukopenia to 114 without steroid-resistant leukopenia. Kidney graft survivals at 2 years were 80.2 plus or minus 8.9 and 48.5 plus or minus 5.3 per cent, respectively (p less than 0.05). The 2-year actuarial patient survivals were not significantly different (89.6 plus or minus 7.0 versus 87.8 plus or minus 3.9 per cent). Azathioprine doses and serum creatinine levels at 1 year were not significantly different. Pre-transplant splenectomy for steroid-resistant leukopenia resulted in a significant decrease in kidney graft losses owing to rejection without an increased risk of death of sepsis or thromboembolism.

• Authors: J M Barry, B Larson, S M Fischer, D J Norman, W M Bennett
• Journal: The Journal of urology (J Urol) Vol. 129 Issue 3 Pg. 479-80 (Mar 1983) ISSN: 0022-5347 [Print] United States
• PMID: 6339747 (Publication Type: Journal Article)

Chemical References

• Azathioprine

Topics

• Azathioprine (therapeutic use)
• Cadaver
• Graft Survival
• Humans
• Kidney Transplantation
• Leukopenia (therapy)
• Splenectomy