Is there an association between Fuchs' endothelial dystrophy and cardiovascular disease?

Abstract

In order to investigate whether there is a clinical association between Fuchs' endothelial dystrophy of the cornea and atherosclerosis, the prevalence of cardiovascular disease was studied retrospectively in 27 patients with Fuchs' dystrophy and in 27 age- and sex-matched controls. The presence of cardiovascular disease was judged from a patient history of myocardial infarction, angina pectoris or heart insufficiency treated by medicaments and was found in 44% of the group with Fuchs' dystrophy and in 11% of the control group (P less than 0.05). The hypothesis is advanced that there may exist a common endothelial factor of possible significance for the development of corneal endothelial dystrophy, as well as the development of atherosclerotic lesions.

• Authors: T Olsen
• Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (Graefes Arch Clin Exp Ophthalmol) Vol. 221 Issue 5 Pg. 239-40 ( 1984) ISSN: 0721-832X [Print] Germany
• PMID: 6333375 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Arteriosclerosis (etiology)
• Cornea (pathology)
• Corneal Dystrophies, Hereditary (complications)
• Endothelium (pathology)
• Female
• Fuchs' Endothelial Dystrophy (complications, pathology)
• Humans
• Male
• Middle Aged
• Retrospective Studies