Efficacy of BW759 (9-[[2-hydroxy-1(hydroxymethyl)ethoxy]methyl]guanine) against herpes simplex virus type 1 keratitis in rabbits.

Abstract

A promising new nucleoside analog, 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy] methyl]-guanine (BW759), which is structurally similar to acyclovir, was tested against acute herpetic keratitis in the rabbit ocular model. Topical 1-0.1% BW759 given 3-5x per day gave beneficial results in that corneal epithelial involvement, conjunctivitis, iritis, and corneal clouding were reduced even when chemotherapy was initiated at 3 days postinoculation. Under the same conditions, topical BW759 therapy gave slightly better results than acyclovir, and both were better than idoxuridine therapy. Mortality rate and colonization of the trigeminal ganglia by HSV-1 were unaffected by BW759 therapy. Duration of virus, shed into the tear film was reduced by BW759.

• Authors: M D Trousdale, A B Nesburn, D E Willey, H Taaid
• Journal: Current eye research (Curr Eye Res) Vol. 3 Issue 8 Pg. 1007-15 (Aug 1984) ISSN: 0271-3683 [Print] England
• PMID: 6333319 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antiviral Agents
• Ointments
• Idoxuridine
• Ganciclovir
• Acyclovir

Topics

• Acyclovir (administration & dosage, analogs & derivatives, therapeutic use)
• Animals
• Antiviral Agents (administration & dosage)
• Chemical Phenomena
• Chemistry
• Conjunctivitis (drug therapy)
• Corneal Opacity (drug therapy)
• Drug Evaluation, Preclinical
• Follow-Up Studies
• Ganciclovir
• Herpes Simplex (drug therapy)
• Idoxuridine (administration & dosage)
• Iritis (drug therapy)
• Keratitis, Dendritic (complications, drug therapy)
• Male
• Neuritis (drug therapy)
• Ointments
• Rabbits
• Time Factors
• Trigeminal Nerve (drug effects)