Amish study, IV: Genetic linkage study of pedigrees of bipolar probands.

Abstract

Genetic linkage studies were conducted on five Old Order Amish bipolar pedigrees in 1979 and 1982, with 94 members tested for color blindness and typed for 42 red blood cell and related markers in 17 antigen systems. Also, 59 individuals in two pedigrees were typed for HLA, Bf, and GLO. Linkage analyses assuming X-linkage and autosomal inheritance of bipolar illness were done with diagnostic schemes ranging from strict bipolar to milder forms of affective disorder. Linkage to affective disorders was not strongly supported for any marker locus. Close linkage to HLA was excluded, with weaker evidence against linkage to GLO.

• Authors: K K Kidd, J A Egeland, L Molthan, D L Pauls, S D Kruger, K H Messner
• Journal: The American journal of psychiatry (Am J Psychiatry) Vol. 141 Issue 9 Pg. 1042-8 (Sep 1984) ISSN: 0002-953X [Print] United States
• PMID: 6331772 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Blood Group Antigens
• Genetic Markers
• HLA Antigens
• Complement Factor B
• Lactoylglutathione Lyase

Topics

• Adolescent
• Adult
• Aged
• Bipolar Disorder (genetics)
• Blood Group Antigens (genetics)
• Child
• Color Vision Defects (genetics)
• Complement Factor B (genetics)
• Depressive Disorder (genetics)
• Ethnicity
• Female
• Genetic Linkage
• Genetic Markers
• HLA Antigens (genetics)
• Humans
• Lactoylglutathione Lyase (genetics)
• Male
• Middle Aged
• Mood Disorders (genetics)
• Pedigree