Epstein-Barr virus-induced lymphoma in a cardiac transplant recipient.

Abstract	A monoclonal diffuse histiocytic lymphoma developed during the course of a serologically documented primary Epstein-Barr virus infection in a 22-year-old cardiac transplant recipient taking cyclosporine and prednisone. Throat washings revealed the virus at tumor presentation, and the tumor was shown to contain Epstein-Barr nuclear antigen-positive cells and the viral genome. Prolonged inversion of the T cell helper/suppressor ratio was demonstrated. A brief course of acyclovir appeared to halt viral shedding in the throat but had no apparent effect on the tumor.
Authors	J S Dummer, L M Bound, G Singh, R W Atchison, S B Kapadia, M Ho
Journal	The American journal of medicine (Am J Med) Vol. 77 Issue 1 Pg. 179-84 (Jul 1984) ISSN: 0002-9343 [Print] United States
PMID	6331161 (Publication Type: Case Reports, Journal Article)
Chemical References	Cyclosporins Prednisone Acyclovir
Topics	Acyclovir (therapeutic use) Adult Burkitt Lymphoma (drug therapy, etiology) Cyclosporins (therapeutic use) Heart Transplantation Herpesvirus 4, Human Humans Immunosuppression Therapy (adverse effects) Male Postoperative Complications Prednisone (therapeutic use)

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