Variations in response of human brain tumors to BCNU in vitro.

Abstract

A microtiter assay was used to study the sensitivity of 24 cultured human astrocytomas to the chemotherapeutic agent 1,3-bis(2-chloroethyl)-1 nitrosourea (BCNU). The tumor cell lines testes originated from patients who were being treated with post-operative chemotherapy within the past 24 months. At a dose level comparable to the maximum in vivo therapeutic dose level, 18 of the 24 cell lines tested showed a significant response to the drug. If in vitro response can eventually be correlated with clinical response, this microtiter assay could help to form a basis for planning more specific chemotherapeutic treatment.

• Authors: P L Kornblith, P E Szypko
• Journal: Journal of neurosurgery (J Neurosurg) Vol. 48 Issue 4 Pg. 580-6 (Apr 1978) ISSN: 0022-3085 [Print] United States
• PMID: 632883 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carmustine

Topics

• Brain Neoplasms (drug therapy)
• Carmustine (therapeutic use)
• Cells, Cultured
• Glioma (drug therapy)
• Humans
• Meningeal Neoplasms (drug therapy)
• Meningioma (drug therapy)