Abstract |
Wistar/Furth rats received chemotherapy with vincristine, actinomycin D and adriamycin alone and in combination following renal subcapsular implantation of a transplantable murine Wilms' tumor and nephrectomy. Each agent prolonged survival significantly compared to control, and both two- drug regimens were superior to single agent therapy. The two- drug programs were equally effective. No drug regimen was effective in preventing abdominal recurrence.
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Authors | D M Green, P D Williams, G P Murphy |
Journal | Oncology
(Oncology)
Vol. 41
Issue 1
Pg. 39-42
( 1984)
ISSN: 0030-2414 [Print] Switzerland |
PMID | 6322086
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dactinomycin
- Vincristine
- Doxorubicin
|
Topics |
- Animals
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Combined Modality Therapy
- Dactinomycin
(administration & dosage)
- Doxorubicin
(administration & dosage)
- Kidney Neoplasms
(drug therapy, mortality, surgery)
- Male
- Neoplasm Recurrence, Local
(prevention & control)
- Neoplasm Transplantation
- Nephrectomy
- Rats
- Rats, Inbred WF
- Vincristine
(administration & dosage)
- Wilms Tumor
(drug therapy, mortality, surgery)
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