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Oral antiviral drugs in experimental herpes simplex keratitis.

Abstract
Chronic oral administration of acyclovir or bromovinyl deoxyuridine to rabbits did not prevent recurrence of virus shedding or clinical corneal disease, nor did it alter the clinical course of recurrences of ocular herpetic disease or result in the appearance of resistant virus in tears.
AuthorsH E Kaufman, E D Varnell, Y M Centifanto-Fitzgerald, E De Clercq, G E Kissling
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 24 Issue 6 Pg. 888-91 (Dec 1983) ISSN: 0066-4804 [Print] United States
PMID6318664 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antiviral Agents
  • brivudine
  • Bromodeoxyuridine
  • Acyclovir
Topics
  • Acyclovir (therapeutic use)
  • Animals
  • Antiviral Agents (therapeutic use)
  • Bromodeoxyuridine (analogs & derivatives, therapeutic use)
  • Female
  • Keratitis, Dendritic (drug therapy, pathology)
  • Male
  • Microbial Sensitivity Tests
  • Rabbits
  • Simplexvirus (drug effects)

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