HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Intranasal interferon alpha 2 for prevention of rhinovirus infection and illness.

Abstract
In two placebo-controlled, double-blind studies, the prophylactic efficacy of recombinant DNA-produced interferon alpha 2 (IFN-alpha 2) against induced rhinovirus (RV) type 39 infection in susceptible volunteers was assessed. IFN-alpha 2 was given by intranasal drops in either multiple treatments (11.4 X 10(6) IU four times per day for four days) or one treatment daily (42.8 X 10(6) IU once per day for five days) starting before RV type 39 challenge. The efficacy rates of multiple-dose IFN-alpha 2 for preventing infection, virus shedding, and RV type 39-specific colds were 78%, 78%, and 100%, respectively. The corresponding rates for one daily treatment were 45%, 64%, and 75%, respectively. Both dosage regimens were associated with significant reductions in days of virus shedding and nasal mucus production. In the second study, three IFN-alpha 2 recipients developed transient leukopenia (less than 4,000 leukocytes/mm3). The results suggest that intranasal IFN-alpha 2 may prove to be a safe and effective method of preventing rhinovirus infection and illness.
AuthorsF G Hayden, J M Gwaltney Jr
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 148 Issue 3 Pg. 543-50 (Sep 1983) ISSN: 0022-1899 [Print] United States
PMID6311914 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Interferon Type I
Topics
  • Administration, Intranasal
  • Adult
  • Common Cold (prevention & control)
  • Double-Blind Method
  • Drug Evaluation
  • Humans
  • Interferon Type I (administration & dosage, adverse effects, therapeutic use)
  • Leukopenia (etiology)
  • Mucus (metabolism)
  • Nasal Mucosa (analysis, metabolism)
  • Rhinovirus

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: