Abstract |
25 patients with sub-perennial idiopathic headache were given tiapride or a placebo in a double-blind controlled trial, over thirteen weeks. Tiapride was given orally in a dosage of 300 mg per day. Blood was drawn in 10 patients and 10 healthy controls for blood prolactin determination. No significant side-effects were recorded during the trial. Statistical analysis of the results is reported. Tiapride proved effective in reducing the frequency of headache (in 65% of patients), with an improvement rate which was statistically significant in comparison to the placebo. The drug seems to improve the headache index itself, although the difference was not statistically significant; however, the number of patients was small.
|
Authors | R Cerbo, M Casacchia, B Boni, R Corona |
Journal | La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris
(Sem Hop)
Vol. 58
Issue 48
Pg. 2839-44
(Dec 30 1982)
France |
Vernacular Title | Etude en double aveugle tiapride contre placebo chez des patients souffrant de céphalées essentielles subcontinues. |
PMID | 6302851
(Publication Type: Clinical Trial, English Abstract, Journal Article)
|
Chemical References |
- Benzamides
- Placebos
- Tiapamil Hydrochloride
|
Topics |
- Adult
- Benzamides
(therapeutic use)
- Chemical Phenomena
- Chemistry
- Clinical Trials as Topic
- Double-Blind Method
- Female
- Headache
(drug therapy)
- Humans
- Male
- Middle Aged
- Placebos
- Tiapamil Hydrochloride
(therapeutic use)
|