beta-Adrenoceptors in the hypertrophied right ventricle of the dog with pulmonary stenosis.

Abstract

1. Right ventricular hypertrophy was produced in dogs by banding of the pulmonary artery for 28 days (n = 7) and results were compared with those in sham-operated dogs (n = 5). 2. Myocardial noradrenaline and adrenaline levels were depressed in both the hypertrophied right ventricle and the non-hypertrophied left ventricle and plasma levels were increased compared to the control dogs. 3. Myocardial beta-adrenoceptors were assessed in membrane preparations of both ventricles by 3H-dihydroalprenolol binding. No change in binding site concentration (pmol/mg membrane protein) or in binding affinity was found in either the hypertrophied right ventricle or in the left ventricle. 4. Divergent results of studies on beta-adrenoceptors in ventricular hypertrophy are difficult to reconcile.

• Authors: M Sturm, R R Taylor
• Journal: Clinical and experimental pharmacology & physiology (Clin Exp Pharmacol Physiol) 1983 Jan-Feb Vol. 10 Issue 1 Pg. 21-6 ISSN: 0305-1870 [Print] Australia
• PMID: 6301714 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Catecholamines
• Receptors, Adrenergic
• Receptors, Adrenergic, beta
• Dihydroalprenolol

Topics

• Animals
• Cardiomegaly (etiology, metabolism)
• Catecholamines (metabolism)
• Dihydroalprenolol
• Dogs
• In Vitro Techniques
• Membranes (metabolism)
• Myocardium (metabolism)
• Pulmonary Valve Stenosis (complications, metabolism)
• Receptors, Adrenergic (metabolism)
• Receptors, Adrenergic, beta (metabolism)