Immunoglobulin E antibodies to pollens augmented in dogs by virus vaccines.

An inbred "atopic dog colony" was established to study the effect of viruses on immunoregulation of immunoglobulin (Ig) E antibodies. Dogs were selected for high skin reactivity to grass and weed pollens. Their offspring were inoculated with pollen extracts in alum immediately after routine vaccinations (attenuated live-virus vaccines for canine distemper and infectious canine hepatitis, and a killed bacterin for Leptospira). Heat labile antipollen IgE antibodies were measured by passive cutaneous anaphylaxis. Pups vaccinated for canine distemper before being given pollen extracts had many more IgE antibodies than did their control littermates who were not vaccinated until after the last pollen extract injection. This may be a natural example of the "allergic break-through phenomenon."
AuthorsO L Frick, D L Brooks
JournalAmerican journal of veterinary research (Am J Vet Res) Vol. 44 Issue 3 Pg. 440-5 (Mar 1983) ISSN: 0002-9645 [Print] UNITED STATES
PMID6301317 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Vaccines, Attenuated
  • Viral Vaccines
  • Immunoglobulin E
  • Adenoviruses, Canine (immunology)
  • Animals
  • Distemper Virus, Canine (immunology)
  • Dog Diseases (genetics, immunology)
  • Dogs
  • Hypersensitivity, Immediate (genetics, immunology, veterinary)
  • Immunoglobulin E (biosynthesis)
  • Intradermal Tests
  • Passive Cutaneous Anaphylaxis
  • Pollen (immunology)
  • Vaccination (veterinary)
  • Vaccines, Attenuated (immunology)
  • Viral Vaccines (immunology)

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